Antibodies to SARS-CoV-2 and risk of past or future sick leave

J Dillner, M Elfström, J Blomqvist, C Eklund, C Lagheden, S Nordqvist-Kleppe, C Hellström, J Olofsson, E Andersson, A Falk, S Bergström, E Hultin, E Pin, A Månberg, P Nilsson, M Hedhammar, S Hober, J Mattsson, S Muhr, K Lundgren

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Received date: 24th September 2020

The extent that antibodies to SARS-CoV-2 may protect against future virus-associated disease is unknown. We invited all employees (n=15,300) at work at the Karolinska University Hosital, Stockholm, Sweden to participate in a study examining SARS-Cov-2 antibodies in relation to registered sick leave.  For consenting 12,928 healthy hospital employees antibodies to SARS-CoV-2 antibodies could be determined and compared to participant sick leave records. Subjects with viral serum antibodies were not at excess risk for future sick leave (adjusted Odds Ratio (OR) controlling for age and sex: 0.85 (95% Confidence Interval (CI) (0.85 (0.43-1.68)). By contrast, subjects with antibodies had an excess risk for sick leave in the weeks prior to testing (adjusted OR in multivariate analysis: 3.34 (2.98-3.74)). Thus, presence of viral antibodies marks past disease and protection against excess risk of future disease. Knowledge of whether exposed subjects have had disease in the past or are at risk for future disease is essential for planning of control measures.  

Read in full at medRxiv.

This is an abstract of a preprint hosted on a preprint server, which is currently undergoing peer review at Scientific Reports. The findings have yet to be thoroughly evaluated, nor has a decision on ultimate publication been made. Therefore, the results reported should not be considered conclusive, and these findings should not be used to inform clinical practice, or public health policy, or be promoted as verified information.

Scientific Reports

Nature Research, Springer Nature