Microbicidal actives with virucidal efficacy against SARS-CoV-2 and other beta- and alpha-coronaviruses: implications for future emerging coronaviruses and other enveloped viruses

M. Ijaz, Raymond Nims, Sifang Zhou, Kelly Whitehead, Vanita Srinivasan, Tanya Kapes, Semhar Fanuel, Jonathan Epstein, Peter Daszak, Joseph Rubino, Julie McKinney

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Received date: 2nd September 2020

Mitigating the risk of acquiring SARS-CoV-2 or other coronaviruses requires awareness of the survival of virus on high-touch environmental surfaces (HITES) and skin, and frequent use of targeted microbicides with virucidal efficacy. We evaluated the efficacies of formulated microbicidal actives against alpha- and beta-coronaviruses, including SARS-CoV-2. Infectious coronaviruses, including severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV-2, human coronavirus 229E, bovine coronavirus, murine hepatitis virus-1, and Middle East respiratory syndrome coronavirus, were deposited on prototypic HITES or spiked into liquid matrices along with organic soil loads. Alcohol-, quaternary ammonium compound-, hydrochloric acid-, organic acid-, p-chloro-m-xylenol-, and sodium hypochlorite-based microbicidal formulations were evaluated per global standardized ASTM International and EN methodologies. All evaluated formulated microbicides inactivated SARS-CoV-2 and other coronaviruses in suspension or on prototypic HITES. Virucidal efficacies ( ≥3 to ≥6 log10 reduction) were displayed within 30 s to 5 min. Coronaviruses, like other lipid-enveloped viruses, are susceptible to commonly used microbicides. We confirmed the virucidal efficacy of a variety of commercially available formulated microbicides against SARS-CoV-2 and other coronaviruses. These formulated microbicidal actives should be useful for targeted surface and hand hygiene and disinfection of liquids, as part of infection prevention and control for SARS-CoV-2 and other emerging enveloped viruses.

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This is an abstract of a preprint hosted on a preprint server, which is currently undergoing peer review at Scientific Reports. The findings have yet to be thoroughly evaluated, nor has a decision on ultimate publication been made. Therefore, the results reported should not be considered conclusive, and these findings should not be used to inform clinical practice, or public health policy, or be promoted as verified information.

Scientific Reports

Nature Research, Springer Nature