Surge of Severe Acute Respiratory Syndrome Coronavirus 2 Infections Linked to Single Introduction of a Virus Strain in Myanmar, 2020

M Nyunt, H Soe, K Aye, W Aung, Y Kyaw, A Kyaw, T Myat, A Latt, M Win, A Win, Y Htun, K Zaw, P Ei, K Hein, L San, N Oo, H Lin, N Mon, K Yee, K Htun, L Aye, Y Ko, T Htoo, K Aung, H Azili, S Han, N Zaw, S Win, W Thwe, T Aye, M Hlaing, W Minn, P Thu, H Thu, Z Htun

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Received date: 11th October 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a major health concern globally. Genomic epidemiology is an important tool to assess the pandemic of the coronavirus disease 2019 (COVID-19). Several mutations have been reported by genome analysis of the SARS-CoV-2. In the present study, we investigate mutational and phylogenetic analysis of 30 whole genome sequences for genomic characteristics of the virus in the specimens collected early phase of pandemic, (March-June, 2020) and sudden surge of infection (August-September, 2020). Phylogenetic analysis revealed that 4 samples of L strain and 1 GR strain in early stage of local transmission, while 6 returnees by rescue flights showed GH (India) and GR strains (China and Philippines) with no evidence of local spread. However, all 19 whole genome sequences in sudden surge of local transmission showed genetically distinct clade GH (Lineage B.1.36). Surge of second wave on SARS-CoV-2 infection was linked to the single-introduction of the GH strain that may be a result of strict restriction of international travel and containment efforts. These genomic data provides the useful information to disease control and prevention strategy.

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This is an abstract of a preprint hosted on a preprint server, which is currently undergoing peer review at Scientific Reports. The findings have yet to be thoroughly evaluated, nor has a decision on ultimate publication been made. Therefore, the results reported should not be considered conclusive, and these findings should not be used to inform clinical practice, or public health policy, or be promoted as verified information.

Scientific Reports

Nature Research, Springer Nature